P Hgf. Hepatocyte growth factor (HGF) is a heterodimeric molecule composed of the αchain and the βchain which are linked by one disulfide bridge (Fig 1) HGF is biosynthesized as a prepro form of 728 amino acids including a signal sequence and both α and βchains After cleavage of a signal peptide of the first 31 amino acids a singlechain HGF is further cleaved between Arg494 and Val495.
Small Molecule Activation Of The Neurotrophin Hepatocyte Growth Factor To Treat Alzheimer Disease from treat Alzheimer disease
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Comparative efficacy and safety of antiHGF/MET pathway
Other targeted therapies have been developed to counteract the deregulation of signal transduction pathways including EGFR and hepatocyte growth factor (HGF)/mesenchymalepithelial transition (MET) pathways11 12 In advanced GC EGFR overexpression occurs in up to 50% of patients13 Similarly abnormal HGF and MET upregulation occurs in GC with MET overexpression in 18%–82% of patients14.
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Hepatocyte growth factor (HGF) or scatter factor (SF) is a paracrine cellular growth motility and morphogenic factorIt is secreted by mesenchymal cells and targets and acts primarily upon epithelial cells and endothelial cells but also acts on haemopoietic progenitor cells and T cells Aliases DFNB39 FTCF HGFB HPTA SF hepatocyte growth factorPDB Ortholog search External IDs .
Small Molecule Activation Of The Neurotrophin Hepatocyte Growth Factor To Treat Alzheimer Disease
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